货号价格

SIG-HM222F-100μg / 询价

SIG-HM222F-500μg / 询价

SIG-HM222F-500μgx2 / 询价

FITC-Labeled Human Siglec-2/CD22 Protein

产品信息(Product Info)
表达区间及表达系统(Source)

Recombinant FITC-Labeled Human Siglec-2/CD22 Protein is expressed from HEK293 with hFc tag at the C-Terminus. It contains Asp20-Arg687.[Accession | P20273-1]

分子量大小(Molecular Weight)

The protein has a predicted MW of 101.9 kDa. Due to glycosylation, the protein migrates to 130-140 kDa based on Tris-Bis PAGE result.

波长(Wavelength)

Excitation Wavelength: 490 nm

Emission Wavelength: 520 nm

内毒素(Endotoxin)

Less than 1EU per μg by the LAL method.

纯度(Purity)

> 95% as determined by Tris-Bis PAGE

制剂(Formulation)

Supplied as 0.22μm filtered solution in PBS (pH 7.4).

存储(Storage)

Valid for 12 months from date of receipt when stored at -80°C.
Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

产品数据(Assay Data)
Tris-Bis PAGE

FITC-Labeled Human Siglec-2/CD22 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

背景(Background)

CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling. It is also involved in the B cell trafficking to Peyer's patches in mice.

分子别名(Synonyms)

CD22 molecule; CD22; Siglec-2; B-cell receptor CD22; BL-CAM; SIGLEC2; SIGLEC2FLJ22814

文献(References)

(1)Kato J , Robert T. O'Donnell, Abuhay M , et al. Efficacy and toxicity of a CD22-targeted antibody-saporin conjugate in a xenograft model of non-Hodgkin's lymphoma[J]. OncoImmunology, 2012, 1(9):7.